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The research in Cimbi focuses on the neural bases of personality dimensions that predispose individuals to affective and substance use disorders, with special emphasis on the serotonergic neurotransmitter system. Both PET and MRI are employed in studies of human subjects, and these are complemented with relevant studies using animal models. Advanced informatics techniques, new tracer compounds, and novel serotonergic challenge paradigms are also being developed within the centre.
The research within Cimbi has been divided into six main projects, which are
1. Molecular brain imaging of the serotonergic system
2. Genetic and biochemical determinants of the serotonergic transmitter system
3. Relation between personality, biochemistry and brain structure
4. Functional brain imaging under serotonergic challenges
5. Development of a PET agonist tracer to probe endogenous serotonin release
6. A meta-analytic approach to knowledge discovery in molecular brain imaging
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